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In studies, all three compounds, as topical treatments, have provided meaningful pain relief in subjects with arthritis.16 17 18 In general, topical anti-inflammatories are similarly effective to their oral counterparts.25 But because of their mechanism of action — soaking into a localized area of skin — topicals tend to pose less of a systemic safety risk, especially among the elderly.28 Which isn’t to say that NOW Solutions doesn’t carry risks